Proton re-irradiation of unresectable recurrent head and neck cancers

Stereotactic Body Radiotherapy for Recurrent Unresectable Head and Neck Cancers.

BACKGROUND Treatment of locoregional, recurrent head and neck cancers following definitive radiotherapy has evolved during the past 30 years. Brachytherapy as well as protracted courses of systemic therapy and chemoradiotherapy result in 12-month survival rates of 40% to 50% but have high rates of severe toxicity. Given the advancements in radiotherapy targeting and delivery, stereotactic body ...

Re-irradiation of unresectable recurrent head and neck cancer: using Helical Tomotherapy as image-guided intensity-modulated radiotherapy

PURPOSE Re-irradiation (re-RT) is considered a treatment option for inoperable locoregionally recurrent head and neck cancer (HNC) after prior radiotherapy. We evaluated the efficacy and safety of re-RT using Helical Tomotherapy as image-guided intensity-modulated radiotherapy in recurrent HNC. MATERIALS AND METHODS Patients diagnosed with recurrent HNC and received re-RT were retrospectively...

Re-irradiation of recurrent head and neck carcinomas: comparison of robust intensity modulated proton therapy treatment plans with helical tomotherapy

BACKGROUND To test the hypothesis that the therapeutic ratio of intensity-modulated photon therapy using helical tomotherapy (HT) for retreatment of head and neck carcinomas can be improved by robust intensity-modulated proton therapy (IMPT). METHODS Comparative dose planning with robust IMPT was performed for 7 patients retreated with HT. RESULTS On average, HT yielded dose gradients steep...

Re-irradiation for recurrent head and neck carcinomas (by Dr. Peponi et al).

Head and neck cancers.